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- Oct 22, 2017
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Potential Benefits of SLU-PP-332
The study on SLU-PP-332 is ongoing; nevertheless, some existing research has demonstrated its potential benefits.①Alleviate Metabolic Syndrome
SLU-PP-332 possesses exercise-mimicking action and significantly reduced obesity and enhanced insulin sensitivity in a rat model of obesity and metabolic syndrome, suggesting that it could be a viable treatment for both conditions.
②Enhance Exercise Capacity
SLU-PP-332 increases cellular respiration and mitochondrial activity in skeletal muscle cell lines. It also produces an acute aerobic exercise gene program unique to ERRα, which improves exercise endurance in mice.
③Improve Heart Failure
ERRγ is a major mediator of ERR agonism-induced transcriptional regulation and cardioprotection and clearly shows targeting specificity. In experiments in mice, SLU-PP-332 significantly improved ejection fraction, improved fibrosis, and increased survival associated with HF caused by pressure overload without affecting cardiac hypertrophy.
④Reverse Mitochondrial Function and Inflammation in the Aging Kidney
ERR is reduced in both aging human and mouse kidneys, whereas ERR remains unchanged in aging mice subjected to lifelong caloric restriction (CR). Eight weeks of treatment with SLU-PP-332 reversed age-related increases in albuminuria, podocyte loss, mitochondrial dysfunction, and inflammatory cytokines.
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