Receptor Freshness

[xxplosive]

Does coming off truly refresh your receptors much when you take a break and go back on? Or is this a myth?

I stayed on for like 2.5-3 years at one point and results kept coming as long as I continued to train and eat correctly. TheRoid from olm i think one time may have said this a myth...

Hate the idea of coming off for 4-8 weeks, losing gains, and spending half the next cycle regaining what was lost in size/definition.

What are your guys thoughts?

 

[01dragonslayer]

Just because something can be upregulated does not necessarily mean it can also be downregulated. But there is no evidence whatsoever on any type of downregulation of androgen receptors with aas use - and there have been plenty of studies looking into the issue.
The only evidence for downregulation comes from studies looking at ZERO androgen activity - not superphysiological levels associated with aas or even normal androgen levels. With zero androgenic activity, it may be possible to dowbregulate ARs - how applicable this is in reality is another issue.

Downregulation also doesn't go with real life results: we would NOT be getting these mass monster bodybuilders if it was possible to saturate the ARs & stop them responding.
Upregulation however does satisfy real life experiences - it may explain why you continue to gain even when way past any sort of genetic limit.

Put simply, there is some evidence to go alongside your anecdotal experiences for upregulation.
There is no evidence for downregulation when dealing with aas use specifically.

 

[xxplosive]

So you are saying that you can blast endlessly and continue to get results?

 

[01dragonslayer]

Like you mentioned....as long as your diet is in check and you are constantly making changes to your routine...resistance, rep ranges, frequency, movements, speed, ROM, etc., etc., etc.,........yes.

 

[Roc]

This will be a good discussion and want to hear from others.

i sware by coming off for 8 or more weeks, totally cleaning out, detoxing, I think the body gets flooded and it can’t do anything else with the drugs. When I come off for a good 8 to 12 weeks and jump back on, it takes me a couple weeks to get my sugar regulated again, I think the body is so fresh that anything will set it off. I do believe test isn’t test, cause why do some pros change every 4-5 weeks. When I take off I blast hcg for the whole time I’m off and still run gh, and don’t loose anything, I keep my diet the same and this is where 98% of the people fall off and shrink.

 

[Natedog]

What’s your hcg routine during your time off

This will be a good discussion and want to hear from others.

i sware by coming off for 8 or more weeks, totally cleaning out, detoxing, I think the body gets flooded and it can’t do anything else with the drugs. When I come off for a good 8 to 12 weeks and jump back on, it takes me a couple weeks to get my sugar regulated again, I think the body is so fresh that anything will set it off. I do believe test isn’t test, cause why do some pros change every 4-5 weeks. When I take off I blast hcg for the whole time I’m off and still run gh, and don’t loose anything, I keep my diet the same and this is where 98% of the people fall off and shrink.

 

[G160]

I have to switch every 3 weeks. Tren wont do shit for me past 3 weeks. Ive tried high doses and i mean up to 3 cc of ace.
All this came down from a 4 month tren deca run. Body never been the same now i constantly find myself switching or going the odd 4 weeks off and reblast.


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[MindlessWork]

I have to switch every 3 weeks. Tren wont do shit for me past 3 weeks. Ive tried high doses and i mean up to 3 cc of ace.
All this came down from a 4 month tren deca run. Body never been the same now i constantly find myself switching or going the odd 4 weeks off and reblast.


Sent from my iPhone using Tapatalk

Maybe your body does not really respond to tren? Like there are some people who don't respond to Test that well despite solid training and diet.

 

[Roc]

This will be a good discussion and want to hear from others.

i sware by coming off for 8 or more weeks, totally cleaning out, detoxing, I think the body gets flooded and it can’t do anything else with the drugs. When I come off for a good 8 to 12 weeks and jump back on, it takes me a couple weeks to get my sugar regulated again, I think the body is so fresh that anything will set it off. I do believe test isn’t test, cause why do some pros change every 4-5 weeks. When I take off I blast hcg for the whole time I’m off and still run gh, and don’t loose anything, I keep my diet the same and this is where 98% of the people fall off and shrink.

500, every 4 days