Rambo - Peptide and SARM Q&A

[OHBRUTUSIO]

Hey man whats ur opinion on Tesamorelin and where would it fit in? Thanks!


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[Quix99]

So regarding what was said about mk..is it a good compound to toss into a cut cycle along with metformin? Or does one need gh added with mk to reap the most benefits?

 

[RamboStallone]

Hey man whats ur opinion on Tesamorelin and where would it fit in? Thanks!


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Sermorelin and tesamorelin were the first peptides introduced to cure gh/igf deficiency. It works but half life is short from what I understand. Now there is literature suggesting half life is actually longer something like 8hrs but its unclear, and since GHRH type peps can be inhibited by somatostatin (negative feedback loop) it makes it hard to determine when to take it for most best results. I used it at 1mg prebed and saw some benefits but bottom line is those peps are outdated technology. Its like using a typewriter, yea it works but a PC is way better. So yes tesamorelin works but I wouldn't waste my time with it when we have cjc 1295, ghrps, and MK677 available to us that are much more effective.

 

[RamboStallone]

So regarding what was said about mk..is it a good compound to toss into a cut cycle along with metformin? Or does one need gh added with mk to reap the most benefits?

No, one does not need HGH. MK677 increases HGH so it is definately not needed to use synthetic HGH with it since it does the same thing! Of course we know stacking PEDs yields better results but MK677 releases natural HGH that consists of several isoforms, I believe 5 total. Synthetic HGH is only 1 isoform so there are advantages to using GH secretagogues like MK677 since you are getting all the HGH isoforms. If this makes a significant difference in benefits I do not fully know. Bottom line is they are both HGH products so they can be used alone or you can stack them if you please to do so just like any other PED.

As far as MK677 in a cut cycle I already covered that. In simple terms, I don't like it during a cut because it increases hunger and there is a bloat and water retention aspect which is great for muscle fullness but can be mind boggling when trying to lose fat. I just don't think its the best choice for a cut cycle but it really depends on the individual and how they react to it since some people do not experience the increase in hunger or water retention or bloat.

Just think about the different gh peps, MK677, and synthetic HGH are like the different forms/esters of testosterone. It is all the same hormone in the end but yet you have people who prefer prop over cyp/enan, or cyp over enan, or sust over enan/cyp. There is no reason for it other then individual reaction and preference.

 

[Quix99]

Awesome. Thanks for the info man

 

[01dragonslayer]

No, one does not need HGH. MK677 increases HGH so it is definately not needed to use synthetic HGH with it since it does the same thing! Of course we know stacking PEDs yields better results but MK677 releases natural HGH that consists of several isoforms, I believe 5 total. Synthetic HGH is only 1 isoform so there are advantages to using GH secretagogues like MK677 since you are getting all the HGH isoforms. If this makes a significant difference in benefits I do not fully know. Bottom line is they are both HGH products so they can be used alone or you can stack them if you please to do so just like any other PED.

As far as MK677 in a cut cycle I already covered that. In simple terms, I don't like it during a cut because it increases hunger and there is a bloat and water retention aspect which is great for muscle fullness but can be mind boggling when trying to lose fat. I just don't think its the best choice for a cut cycle but it really depends on the individual and how they react to it since some people do not experience the increase in hunger or water retention or bloat.

Just think about the different gh peps, MK677, and synthetic HGH are like the different forms/esters of testosterone. It is all the same hormone in the end but yet you have people who prefer prop over cyp/enan, or cyp over enan, or sust over enan/cyp. There is no reason for it other then individual reaction and preference.

Great info....Thanks Rambo.

 

[RamboStallone]

Awesome. Thanks for the info man

Great info....Thanks Rambo.

Of course, no problem. I enjoy these questions because they make me dig deep in the back of my mind. Keep them coming guys!

 

[Kins]

Hey Rambo-every time insulin goes up Gh goes down. So when taking MK does it need to be on a low carb diet or on an empty stomach?. Last time I used it I was on low carb, so I'm not sure how it works when eating carbs. I still miss it because when I was using it I was the strongest I've ever been that I can remember. My skin was also amazingly clear. I just can't go over 10 mg or I get the crazy bloat.

 

[RamboStallone]

Hey Rambo-every time insulin goes up Gh goes down. So when taking MK does it need to be on a low carb diet or on an empty stomach?. Last time I used it I was on low carb, so I'm not sure how it works when eating carbs. I still miss it because when I was using it I was the strongest I've ever been that I can remember. My skin was also amazingly clear. I just can't go over 10 mg or I get the crazy bloat.

Generally speaking in a "normal" person yes usually when one is high the other is low but that is not always the case. Regardless, once you alter this with PEDs the rules are out the window anyway. So no you do not need to be low carb or fasted. Matter of fact I had to usually eat or else I'd go hypo so I always ate or had food in me when using it especially since it makes me soo hungry!!!

10mg is a good dose bro, it released almost as much gh as 50mg. I'll pull the study.

 

[RamboStallone]

Generally speaking in a "normal" person yes usually when one is high the other is low but that is not always the case. Regardless, once you alter this with PEDs the rules are out the window anyway. So no you do not need to be low carb or fasted. Matter of fact I had to usually eat or else I'd go hypo so I always ate or had food in me when using it especially since it makes me soo hungry!!!

10mg is a good dose bro, it released almost as much gh as 50mg. I'll pull the study.

https://www.ncbi.nlm.nih.gov/pubmed/9329386

Serum IGF-i and 24-H mean GH concentrations increased in all subjects after treatment with both 10 and 50 mg/day MK-677 vs. baseline. After treatment with 10 mg MK-677, IGF-I concentrations increased 52 +/- 20% (65 +/- 6 to 99 +/- 9 micrograms/L, geometric mean +/- intrasubject SE, P < or = 0.05 vs. baseline), and 24 h mean GH concentrations increased 79 +/- 19% (0.14 +/- 0.01 to 0.26 +/- 0.02 microgram/L, P < or = 0.05 vs. baseline). Following treatment with 50 mg MK-677, IGF-I concentrations increased 79 +/- 9% (84 +/- 3 to 150 +/- 6 micrograms/L, P < or = 0.05 vs. baseline) and 24-h mean GH concentrations increased 82 +/- 29% (0.21 +/- 0.02 to 0.39 +/- 0.04 microgram/L, P < or = 0.05 vs. baseline), respectively.

In summary,

10mg igf increase of 52 points, gh increase of 79 points
50mg igf increase of 79 points, gh increase 82 points

As you can see the both doses had similar HGH levels but IGF levels were higher with higher dose.

 

[Kins]

Thank you so much Rambo!.

 

[OHBRUTUSIO]

Whats a good female dose of mk? She is also doing 100 mcg of iPam. I am also doing Ipam @ 200mcgs / 500 Hex and will add 12.5 mgs of mk. How will this compare to hgh? MK bloats me but Im hoping itll work this time. Any hints for not bloating on MK?


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[RamboStallone]

Whats a good female dose of mk? She is also doing 100 mcg of iPam. I am also doing Ipam @ 200mcgs / 500 Hex and will add 12.5 mgs of mk. How will this compare to hgh? MK bloats me but Im hoping itll work this time. Any hints for not bloating on MK?


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5mg is a good dose for female, start her at 2.5mg. She can work up to 10mg, I don't think she'd need anymore then that.

To mitigate sides you start low and work up as I explained earlier. Start low at 2.5-5mg a day for the first week and go up in dose 2.5mg every week, as long as there are no sides, till you reach your desired dose. If there are sides, wait at least another week for sides to subside before going up. Don't start right away with 12.5mg or you will get hit with sides immediately. The longer you stick with it the less the sides will become. I ran it for a year once, it got to the point where I was not feeling any sides so I began to question the legitimacy of the product so I stopped taking it for a week or so. As soon as I restarted at the same dose, sides hit me like a brick wall. I mainly get lethargy and hunger that makes it unbearable to function since all I want to do is eat and sleep lol.

 

[OHBRUTUSIO]

5mg is a good dose for female, start her at 2.5mg. She can work up to 10mg, I don't think she'd need anymore then that.

To mitigate sides you start low and work up as I explained earlier. Start low at 2.5-5mg a day for the first week and go up in dose 2.5mg every week, as long as there are no sides, till you reach your desired dose. If there are sides, wait at least another week for sides to subside before going up. Don't start right away with 12.5mg or you will get hit with sides immediately. The longer you stick with it the less the sides will become. I ran it for a year once, it got to the point where I was not feeling any sides so I began to question the legitimacy of the product so I stopped taking it for a week or so. As soon as I restarted at the same dose, sides hit me like a brick wall. I mainly get lethargy and hunger that makes it unbearable to function since all I want to do is eat and sleep lol.

Lololol. Forgot about the hunger sides. I will try that. Should just say F it and jump on the HGH train. We really only want it for the skin enhancements w aging but arent seeing enough concrete anicdotal evidence that it really works well for that


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