1+2 on Somedin (IGF1-DES) for loggers, yes you heard right - 1+2 for free
- Thread starter Sciroxx
- Start date
- Thread starter
- #23
Yes for u
you guys rock I think I will be sending friends of mine your way and I'm going to be a customer for life
thank you guys,for once in my life a fucking wish came true lol i can't believe it.
- Thread starter
- #25
You may check out here some valuable info and feedback on the somedin
https://hardcore-underground.com/showthread.php/2201-IGF1-by-Sciroxx/page1?p=26958#post26958
https://hardcore-underground.com/showthread.php/2201-IGF1-by-Sciroxx/page1?p=26958#post26958
- Thread starter
- #26
Hereinafter you may see some scientific literature that confirms the extremely high potency of the IGF1-DES as well as some indications for therapeutic applications for it
ormat: AbstractSend to
Int J Biochem Cell Biol. 1996 Oct;28(10):1085-7.
Des(1-3)IGF-I: a truncated form of insulin-like growth factor-I.
Ballard FJ1, Wallace JC, Francis GL, Read LC, Tomas FM.
Author information
Abstract
Des(1-3)IGF-I, a truncated variant of human IGF-I with the tripeptide Gly-Pro-Glu absent from the N-terminus, has been isolated from bovine colostrum, human brain and porcine uterus. This protein probably results from post-translational cleavage of IGF-I. Des(1-3)IGF-I generally is about 10-fold more potent than IGF-I at stimulating hypertrophy and proliferation of cultured cells, a consequence of much reduced binding to IGF-binding proteins, in turn caused by the absence of the glutamate at position 3. The increased potency is retained in part when the variant is administered in vivo, with selective anabolic effects particularly evident in gut tissues. Clinical opportunities for des(1-3)IGF-I have not yet been evaluated, but could apply in catabolic states as well as for the treatment of inflammatory bowel diseases.
ormat: AbstractSend to
Int J Biochem Cell Biol. 1996 Oct;28(10):1085-7.
Des(1-3)IGF-I: a truncated form of insulin-like growth factor-I.
Ballard FJ1, Wallace JC, Francis GL, Read LC, Tomas FM.
Author information
Abstract
Des(1-3)IGF-I, a truncated variant of human IGF-I with the tripeptide Gly-Pro-Glu absent from the N-terminus, has been isolated from bovine colostrum, human brain and porcine uterus. This protein probably results from post-translational cleavage of IGF-I. Des(1-3)IGF-I generally is about 10-fold more potent than IGF-I at stimulating hypertrophy and proliferation of cultured cells, a consequence of much reduced binding to IGF-binding proteins, in turn caused by the absence of the glutamate at position 3. The increased potency is retained in part when the variant is administered in vivo, with selective anabolic effects particularly evident in gut tissues. Clinical opportunities for des(1-3)IGF-I have not yet been evaluated, but could apply in catabolic states as well as for the treatment of inflammatory bowel diseases.
