- Dec 2, 2024
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SLU-PP-332 is a synthetic molecule that acts as an agonist for estrogen-related receptors (ERRs), particularly ERRα. These receptors are involved in regulating various metabolic processes, and SLU-PP-332's activation of these receptors leads to a range of effects, mimicking some of the benefits of exercise.
Benefits:
Increased Energy Expenditure: Studies have shown that SLU-PP-332 can increase energy expenditure, leading to potential weight loss and improved metabolic health.
Improved Insulin Sensitivity: It has also been shown to improve insulin sensitivity, suggesting a potential therapeutic role in managing metabolic syndrome and type 2 diabetes.
Enhanced Exercise Endurance: Research indicates that SLU-PP-332 can improve exercise endurance, likely due to its effects on mitochondrial function and fatty acid metabolism.
SLU-PP-332:
What it is:
ERR Agonist: SLU-PP-332 is a synthetic small molecule that specifically activates estrogen-related receptors (ERRs), which are nuclear receptors involved in metabolic regulation.
Exercise Mimetic: It is often referred to as an "exercise mimetic" because it can trigger metabolic changes similar to those induced by physical activity.
Mechanism of Action:
ERR Activation: SLU-PP-332 binds to and activates ERRs, especially ERRα, influencing the expression of genes involved in energy metabolism.
Mitochondrial Function: Activation of ERRs by SLU-PP-332 leads to increased mitochondrial biogenesis and function, enhancing cellular respiration.
Fatty Acid Oxidation: SLU-PP-332 promotes fatty acid oxidation, shifting the body's fuel source towards fats, similar to the metabolic changes observed during endurance exercise.
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