A Quick Look at the Hottest Fat-Loss Peptides Right Now (2025 Edition)

[AASraw]

Hello everyone,

Been seeing a ton of new logs and discussions lately, so here’s a clean comparison of what’s actually moving the needle in 2025:

Peptide	Class	Primary Mechanism	Current Street Popularity	Typical Weekly Dose (research use)
Semaglutide	GLP-1	Appetite suppression + delayed gastric emptying	Extremely high	0.5–2.4 mg
Tirzepatide	Dual GLP-1/GIP	Stronger satiety + better glucose disposal	King right now	5–15 mg
Retatrutide	Triple GLP-1/GIP/Glucagon	Insane fat oxidation + energy expenditure	Exploding (hard to find)	4–12 mg
Cagrilintide	Amylin analog	Pure appetite control, stacks perfectly with GLP-1	Rising fast	2.4–4.8 mg
Eloralintide	Next-gen amylin	Even longer half-life than Cagrilintide	Very new, limited supply	Research only
Survodutide	Dual GLP-1/Glucagon	Aggressive fat loss + liver fat reduction	Phase III hype	3–6 mg
AOD9604	GH fragment 177-191	Direct lipolysis, no effect on IGF-1	Old but still loved	300–500 mcg/day
MOTS-c	Mitochondrial peptide	AMPK activation, fat metabolism	Underground favorite	5–10 mg

Disclaimer: Sourced from the internet

Real-world feedback in 2025:

Tirzepatide still dominates for pure body recomp
Retatrutide is a new choice
Cagrilintide + Semaglutide/Tirzepatide stacks are giving insane fullness with almost zero nausea
AOD9604 and MOTS-c remain go-to for people who want fat loss without appetite sides

Stable bulk/raw supply (all of the above) is available through AASraw right now if anyone’s setting up larger runs.

What are you guys running or planning for 2026? Drop your current stack below.

 

[tbfofdsm]

Hello everyone,

Been seeing a ton of new logs and discussions lately, so here’s a clean comparison of what’s actually moving the needle in 2025:

Peptide	Class	Primary Mechanism	Current Street Popularity	Typical Weekly Dose (research use)
Semaglutide	GLP-1	Appetite suppression + delayed gastric emptying	Extremely high	0.5–2.4 mg
Tirzepatide	Dual GLP-1/GIP	Stronger satiety + better glucose disposal	King right now	5–15 mg
Retatrutide	Triple GLP-1/GIP/Glucagon	Insane fat oxidation + energy expenditure	Exploding (hard to find)	4–12 mg
Cagrilintide	Amylin analog	Pure appetite control, stacks perfectly with GLP-1	Rising fast	2.4–4.8 mg
Eloralintide	Next-gen amylin	Even longer half-life than Cagrilintide	Very new, limited supply	Research only
Survodutide	Dual GLP-1/Glucagon	Aggressive fat loss + liver fat reduction	Phase III hype	3–6 mg
AOD9604	GH fragment 177-191	Direct lipolysis, no effect on IGF-1	Old but still loved	300–500 mcg/day
MOTS-c	Mitochondrial peptide	AMPK activation, fat metabolism	Underground favorite	5–10 mg

Disclaimer: Sourced from the internet

Real-world feedback in 2025:

Tirzepatide still dominates for pure body recomp
Retatrutide is a new choice
Cagrilintide + Semaglutide/Tirzepatide stacks are giving insane fullness with almost zero nausea
AOD9604 and MOTS-c remain go-to for people who want fat loss without appetite sides

Stable bulk/raw supply (all of the above) is available through AASraw right now if anyone’s setting up larger runs.

What are you guys running or planning for 2026? Drop your current stack below.

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